01 · BLOOD
Angiogenesis & blood vessel patterning
How endothelial cells sprout, migrate, and assemble into a patterned network of arteries and veins — and the signals that tell a vessel where to grow.
Blood and lymphatic vessels reach nearly every tissue in the body. We study how they are built during development, how the same programs are redeployed in disease and regeneration, and how that knowledge might be turned into therapy. Zebrafish are transparent for their first days of life, letting us watch vessels form in a living animal in real time.
How endothelial cells sprout, migrate, and assemble into a patterned network of arteries and veins — and the signals that tell a vessel where to grow.
How lymphatic endothelial cells are specified and separated from the blood vasculature, and what this tells us about lymphedema and lymphatic disease.
Mapping the redundancy within the VEGF family to understand how tumors and diseased tissue escape anti-VEGFA therapies — and engineering tools to block that escape.
Using zebrafish and mouse as living models to ask how vascular networks fail in disease, and how revascularization supports tissue repair and regeneration.